I too am having issues with the new Daedalus 4.5.0 update. I cannot connect the cardano node, ever. It’ll run for hours and nothing. I setup my wallet on my laptop and it took 5 hours to synchronize and connect, but as soon as I closed the app and opened it up, same issue - not able to connect (both desktop, laptop). I’ve reset all the computers. I’ve reset the internet/modem. I’ve made sure all computers are up to date.
Nothing else has changed on my setup except the new update.
I’ve reached out to IOHK team and they basically give me a generic answer, it’s really not useful at all.